The north is characterized by very hot, humid summers with mild drier winters, and is subject to periodic droughts. Central Argentina has hot summers with thunderstorms (western Argentina produces some of the world's largest hail), and cool winters. The southern regions have warm summers and cold winters with heavy snowfall, especially in mountainous zones. Higher elevations at all latitudes experience cooler conditions.

The hottest and coldest temperature extremes recorded in South America have occurred in Argentina. A record high temperature of 49.1 °C (120.4 °F), was recorded at Villa María, Córdoba, on 2 January 1920. The lowest temperature recorded was −39 °C (−38.2 °F) at Valle de los Patos Superior, San Juan, on 17 July 1972.

Major wind currents include the cool Pampero Winds blowing on the flat plains of Patagonia and the Pampas; following the cold front, warm currents blow from the north in middle and late winter, creating mild conditions. The Zonda, a hot dry wind, affects west-central Argentina. Squeezed of all moisture during the 6,000 m (19,685 ft) descent from the Andes, Zonda winds can blow for hours with gusts up to 120 km/h (75 mph), fueling wildfires and causing damage; when the Zonda blows (June–November), snowstorms and blizzard (viento blanco) conditions usually affect higher elevations.

The Sudestada ("southeasterlies") could be considered similar to the Nor'easter, though snowfall is rare but not unprecedented. Both are associated with a deep winter low pressure system. The sudestada usually moderates cold temperatures but brings very heavy rains, rough seas and coastal flooding. It is most common in late autumn and winter along the central coast and in the Río de la Plata estuary.

The southern regions, particularly the far south, experience long periods of daylight from November to February (up to nineteen hours) and extended nights from May to August.